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American Indians had never been exposed to the diseases Europeans brought with them, and consequently lacked the immunities Europeans had built up over countless generations of exposure. Further, Indian religious leaders and Elders complained bitterly when young people in their towns began to rely on European trade goods guns, knives, iron kettles instead of making their own tools in the traditional way.The proselytizing of Christian missionaries was especially reviled.
For example, Jean Baptiste Pont du Sable, who founded Chicago was a Creole.
As the French expanded their base of control, some Indian Nations simply packed up and moved, not wanting even to be near the French and their strange religion and habits.
But dislocated Indians had to live somewhere, and they invariably wound up in the proximity of other Indian communities, threatening the resources of the people who were already there.
There is still a large community of Creoles in Louisiana today. It is said that, as intermediaries between the Blacks and the whites, they got European instruments into the hands of African musicians and thereby facilitated the development of jazz.
In New England we find Cape Verdians, Africans who migrated here in the 18th and 19th century aboard whaling ships that stopped in Cabo Verde, an island off the coast of West Africa, to resupply and pick up extra hands.