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Key words: docking, homology modeling, leprosy, M.leprae, molecular, molecular dynamics, ramachandran plot. Therefore identification of the novel drug target and potent drug can be helpful in better prevention of the disease. Alter et.al, (2008) Leprosy as a genetic model for susceptibility to common infectious disease, Hum Genet 2. (1999)Health Policy and Planning; 14(2): 89-102, Oxford University Press. Results show that the hydraulic resistance is significantly reduced in the proposed four ports actuators; and the proposed cylinders run faster than the conventional cylinders and a considerable amount of energyis saved as well. Key words: Computational Hydraulic, Energy Efficient Actuators, Energy Saving in Hydraulic, Hydraulic Control Reference [1] P. However, no computer can process the near infinite number of atoms in objects, so instead we model 'finite' groups of them. In the real world, everything that occurs results from the interaction between atoms (and sub-particles of those atoms). If we were to simulate the world in a computer, we would have to simulate this interaction based on the simple laws of physics. Domenico Prattichizzo,, and Antonio Bicchi,"Dynamic "Analysis of Mobility and Graspability of General Manipulation Systems" IEEE transactions on robotics and automation, vol. This paper presents a review of PSO application in Economic Load Dispatch problems. The proposed four ports cylinder was simulated and parameters such as ports sizes, loads and pressures are varied during the simulation. The hydraulic resisting forces, piston speed and mass flow rates are computed. Chenoweth, Aircraft flight control actuation system design vol.

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The study investigates and analyzes the possibilities of reducing the hydraulic resistance and increasing efficiency of the hydraulic actuator.

Stukenbrock, "Toward maximum flexibility in working machinery, iht control in a mecalac excavator," 2004. Yao, "Energy-saving control of singlerod hydraulic cylinders with programmable valves and improved working mode selection," 2002. Eriksson, "Control Strategy for Energy Efficient Fluid Power Actuators: Utilizing Individual Metering," SE-581 83 Linköping, Sweden: Linköping University, 2007. There are various field of power system in which PSO is successfully applied.

(April 2003), "Nanometer stepping drives of surface acoustic wave motor", IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 50, IEEE, pp. Due to its higher quality solution including mathematical simplicity, fast convergence & robustness it has become popular for many optimization problems.

Krus, "On Load Sensing Fluid Power Systems," Division of Fluid Power Control Department of Mechanical Engineering, Linkoping University, Sweden, 1988.

Palmberg, "Hydraulic transformers-comparison of different designs," 2004.

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